Prosperity
Pro
Очередная реакция на отравление ивермектином, абсолютно здоровому жеребенку по ошибке дали двойную дозу, вот к чему это привело.
К счастью, после интенсивной терапии он выздоровел. Полный текст:
What’s your diagnosis?
A previously alert and healthy 2-week-old foal presented at Hagyard’s McGee Medicine Center in mid-2015 with the following symptoms: unsteadiness, depression and lethargy, as illustrated in this video. The foal stood and nursed normally after birth. Other than a recent deworming, this foal had been given no out-of-the-ordinary medications or supplements. Can you guess what condition we diagnosed this foal with?
EDITED TO ADD ANSWER: The diagnosis was ivermectin toxicity. In this case, the foal had been given about twice the dose indicated for his size. Ivermectin is generally safe in adult horses, with caution given to administering to animals with chronic disease, severe weight loss or other debilitating condition. However, in very young horses, ivermectin can cause a toxic effect. Ivermectin belongs to the “avermectin” group of anti-parasitics, which work by increasing the inhibitory neurotransmitter gamma aminobutyric acid (GABA). This compound blocks transmissions between nerves, which causes paralysis and death for parasites.
GABA is present in the central nervous system (brain and spinal cord) of horses. The “blood-brain barrier” protects the brain and spinal cord by blocking certain substances from entering through a large mechanism of capillaries. The avermectins do not cross the blood-brain barrier of adults as the barrier is fully developed. Conversely, it is not fully developed in young horses, so the avermectins can cross, which can create severe problems in the brain and spinal cord, leading to neurological deficiencies. The blood brain barrier is commonly thought to be completely closed by 2 months of age, so it is much safer to use ivermectin in horses older than 2 months.
Symptoms include unsteadiness (ataxia), depression, lethargy and even coma. If a foal becomes neurologic after ivermectin, your veterinarian will provide supportive care through oral and intravenous fluids, vitamin E (a powerful antioxidant), anti-inflammatories and close monitoring. Praziquantel, pyrantel pamoate, and fenbendazole are much safer alternatives for deworming neonates. Please contact your veterinarian to determine a tailored deworming plan that is right for your horse’s exact needs.
With supportive care at Hagyard, this foal survived with no lasting effects.
--Dr. Katherine DeHaan and Dr. Nathan Slovis
*This video is used with the permission of the foal’s owners.
К счастью, после интенсивной терапии он выздоровел. Полный текст:
What’s your diagnosis?
A previously alert and healthy 2-week-old foal presented at Hagyard’s McGee Medicine Center in mid-2015 with the following symptoms: unsteadiness, depression and lethargy, as illustrated in this video. The foal stood and nursed normally after birth. Other than a recent deworming, this foal had been given no out-of-the-ordinary medications or supplements. Can you guess what condition we diagnosed this foal with?
EDITED TO ADD ANSWER: The diagnosis was ivermectin toxicity. In this case, the foal had been given about twice the dose indicated for his size. Ivermectin is generally safe in adult horses, with caution given to administering to animals with chronic disease, severe weight loss or other debilitating condition. However, in very young horses, ivermectin can cause a toxic effect. Ivermectin belongs to the “avermectin” group of anti-parasitics, which work by increasing the inhibitory neurotransmitter gamma aminobutyric acid (GABA). This compound blocks transmissions between nerves, which causes paralysis and death for parasites.
GABA is present in the central nervous system (brain and spinal cord) of horses. The “blood-brain barrier” protects the brain and spinal cord by blocking certain substances from entering through a large mechanism of capillaries. The avermectins do not cross the blood-brain barrier of adults as the barrier is fully developed. Conversely, it is not fully developed in young horses, so the avermectins can cross, which can create severe problems in the brain and spinal cord, leading to neurological deficiencies. The blood brain barrier is commonly thought to be completely closed by 2 months of age, so it is much safer to use ivermectin in horses older than 2 months.
Symptoms include unsteadiness (ataxia), depression, lethargy and even coma. If a foal becomes neurologic after ivermectin, your veterinarian will provide supportive care through oral and intravenous fluids, vitamin E (a powerful antioxidant), anti-inflammatories and close monitoring. Praziquantel, pyrantel pamoate, and fenbendazole are much safer alternatives for deworming neonates. Please contact your veterinarian to determine a tailored deworming plan that is right for your horse’s exact needs.
With supportive care at Hagyard, this foal survived with no lasting effects.
--Dr. Katherine DeHaan and Dr. Nathan Slovis
*This video is used with the permission of the foal’s owners.
и уже даже не один десяток.
